Intramural Funding

Through, for example, start-up financing for highly innovative projects and clinical studies, NeuroCure can react flexibly and quickly to new trends in the neurosciences. The granting of funds is carried out efficiently and transparently based on award procedures that have been worked out according to high Quality standards.

The following funding programs are available to NeuroCure members:
 
Flexible Funds:
Funding is available for selected clinical projects of NeuroCure Principal Investigators. Start-up funding is granted for two years and directed primarily towards “proof-of-concept studies”, which subject findings from basic science to clinical testing for the first time. Applications are evaluated in a competitive two-level internal evaluation procedure.
Please find more information here.
 
Dual-PI Projects:
The Cluster aims to support collaborations between two NeuroCure research groups and offers funding for initiating collaborative research projects that will lead to significant preliminary data and ultimately enable grant applications to national and international funding agencies.
Supported Dual-PI projects

Britta Eickholt and Christian Rosenmund
Analyses of PI3K/mT or signaling as common defect underlying neurodevelopmental disorders

Publication:
Sampathkumar, C., Y. J. Wu, M. Vadhvani, T. Trimbuch, B. Eickholt, and C. Rosenmund. "Loss of Mecp2 Disrupts Cell Autonomous and Autocrine Bdnf Signaling in Mouse Glutamatergic Neurons." Elife 5 (Oct 26 2016). http://dx.doi.org/10.7554/eLife.19374.

Follow-up project:
“Common functions of PTEN and MeCP2, two genes affected in ASD” funded by the Simons Foundation (USA).


Matthias Endres and Helmut Kettenmann
Functional muscarinic acetycholine receptors control microglia/brain macrophage properties after stroke

Publication:
Pannell, M., M. A. Meier, F. Szulzewsky, V. Matyash, M. Endres, G. Kronenberg, V. Prinz, S. Waiczies, S. A. Wolf, and H. Kettenmann. "The Subpopulation of Microglia Expressing Functional Muscarinic Acetylcholine Receptors Expands in Stroke and Alzheimer's Disease." Brain Struct Funct 221, no. 2 (Mar 2016): 1157-72. http://dx.doi.org/10.1007/s00429-014-0962-y.


James Poulet and Andrew Plested
Optical silencing and recording of neurotransmission in the mammalian brain

Follow-up projects:
“Excitatory synapses: from structural biology to optical control” funded by the DFG (Heisenberg Professorship)
“Optical control of glutamate receptors using genetically encoded unnatural amino acids” funded by the DFG (PL619)
“Optical control and report of synaptic transmission”, Wellcome Trust Senior Fellowship (UK), declined


Josef Priller and Erich Wanker
Reinforcement learning in frontotemporal dementia and in Drosophila models of TDP-43 proteinopathy

Publications:
Lorenz, C., P. Lesimple, R. Bukowiecki, A. Zink, G. Inak, B. Mlody, M. Singh, M. Semtner, N. Mah, K. Aure, M. Leong, O. Zabiegalov, E. M. Lyras, V. Pfiffer, B. Fauler, J. Eichhorst, B. Wiesner, N. Huebner, J. Priller, T. Mielke, D. Meierhofer, Z. Izsvak, J. C. Meier, F. Bouillaud, J. Adjaye, M. Schuelke, E. E. Wanker, A. Lombes, and A. Prigione. "Human Ipsc-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological Mtdna Disorders." Cell Stem Cell 20, no. 5 (May 04 2017): 659-74 e9. http://dx.doi.org/10.1016/j.stem.2016.12.013.

Vopel, T., K. Bravo-Rodriguez, S. Mittal, S. Vachharajani, D. Gnutt, A. Sharma, A. Steinhof, O. Fatoba, G. Ellrichmann, M. Nshanian, C. Heid, J. A. Loo, F. G. Klarner, T. Schrader, G. Bitan, E. E. Wanker, S. Ebbinghaus, and E. Sanchez-Garcia. "Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer Clr01." J Am Chem Soc 139, no. 16 (Apr 26 2017): 5640-43.http://dx.doi.org/10.1021/jacs.6b11039.

Sin, O., T. de Jong, A. Mata-Cabana, M. Kudron, M. A. Zaini, F. A. Aprile, R. I. Seinstra, E. Stroo, R. W. Prins, C. N. Martineau, H. H. Wang, W. Hogewerf, A. Steinhof, E. E. Wanker, M. Vendruscolo, C. F. Calkhoven, V. Reinke, V. Guryev, and E. A. Nollen. "Identification of an Rna Polymerase Iii Regulator Linked to Disease-Associated Protein Aggregation." Mol Cell 65, no. 6 (Mar 16 2017): 1096-108 e6. http://dx.doi.org/10.1016/j.molcel.2017.02.022.

Nickchen, K., R. Boehme, M. Del Mar Amador, T. D. Halbig, K. Dehnicke, P. Panneck, J. Behr, K. Prass, A. Heinz, L. Deserno, F. Schlagenhauf, and J. Priller. "Reversal Learning Reveals Cognitive Deficits and Altered Prediction Error Encoding in the Ventral Striatum in Huntington's Disease." Brain Imaging Behav (Dec 05 2016). http://dx.doi.org/10.1007/s11682-016-9660-0.

Zografos, L., J. Tang, F. Hesse, E. E. Wanker, K. W. Li, A. B. Smit, R. W. Davies, and J. D. Armstrong. "Functional Characterisation of Human Synaptic Genes Expressed in the Drosophila Brain." Biol Open 5, no. 5 (May 15 2016): 662-7. http://dx.doi.org/10.1242/bio.016261.

Stroedicke, M., Y. Bounab, N. Strempel, K. Klockmeier, S. Yigit, R. P. Friedrich, G. Chaurasia, S. Li, F. Hesse, S. P. Riechers, J. Russ, C. Nicoletti, A. Boeddrich, T. Wiglenda, C. Haenig, S. Schnoegl, D. Fournier, R. K. Graham, M. R. Hayden, S. Sigrist, G. P. Bates, J. Priller, M. A. Andrade-Navarro, M. E. Futschik, and E. E. Wanker. "Systematic Interaction Network Filtering Identifies Crmp1 as a Novel Suppressor of Huntingtin Misfolding and Neurotoxicity." Genome Res 25, no. 5 (May 2015): 701-13. http://dx.doi.org/10.1101/gr.182444.114.

Follow-up project:
 “Effects of Huntingtin Seeding on Neurodegeneration, Behavior and Life Span in an Inducible Drosophila Model of Huntington’s Disease” funded by the Cure Huntington’s Disease Initiative Foundation (USA)


Markus Schülke-Gerstenfeld and Stephan Sigrist
Discovery of novel disease genes involved in the development of the peripheral nervous system and their functional evaluation in the Drosophila model

Publications:
Knierim, E., H. Hirata, N. I. Wolf, S. Morales-Gonzalez, G. Schottmann, Y. Tanaka, S. Rudnik-Schoneborn, M. Orgeur, K. Zerres, S. Vogt, A. van Riesen, E. Gill, F. Seifert, A. Zwirner, J. Kirschner, H. H. Goebel, C. Hubner, S. Stricker, D. Meierhofer, W. Stenzel, and M. Schuelke. "Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures." Am J Hum Genet 98, no. 3 (Mar 03 2016): 473-89. http://dx.doi.org/10.1016/j.ajhg.2016.01.006.

Straussberg, R., G. Schottmann, M. Sadeh, E. Gill, F. Seifert, A. Halevy, K. Qassem, J. Rendu, P. F. van der Ven, W. Stenzel, and M. Schuelke. "Kyphoscoliosis Peptidase (Ky) Mutation Causes a Novel Congenital Myopathy with Core Targetoid Defects." Acta Neuropathol 132, no. 3 (Sep 2016): 475-8. http://dx.doi.org/10.1007/s00401-016-1602-9.


Imre Vida and Dietmar Schmitz
Spatial organization of inhibitory microcircuit of the grid cell navigation system in the rat entorhinal cortex

 
Innovation Projects:
Funding is granted to innovative risk projects that may take the form of new project ideas or follow-up projects connected to existing, already funded measures. Funding may be applied to personnel and material costs as well as investments.
 
Female Postdoctoral Research Fellowships:
As part of its effort to support female scientists in their career, NeuroCure has established Female Postdoctoral Research Fellowships to promote, in particular, female postdoctoral researchers with a strong interest in continuing their career towards an independent faculty Position.
Awarded Fellowships
The following scientists have been awarded a two-year NeuroCure Female Postdoctoral Researcher Fellowship:
2015:
Natalia Kononenko
Natalia Kononenko's research focuses on neurotrophin signalling, endocytic trafficking and neurodegeneration. In 2016 Dr. Kononenko moved to the Cluster of Excellence CECAD at the University of Cologne to head a junior research group.
Nevena Milenkovic Zujko
Nevena Milenkovic Zujko's research investigates the neural basis of thermal processing and perception in a transgenic mammalian model system, the mouse forepaw.
Ulrike Pannasch
Ulrike Pannasch's research focuses on the interplay between astrocytes and neurons during synaptic transmission and plasticity. In November 2015 Dr. Pannasch was recruited as Scientific Coordinator by the College for Life Sciences Berlin.
Miranka Wirth
Miranka Wirth's research investigates neurophysiological mechanisms and determinants of brain and cognitive health.
2014
Anna Carbone
Anna Carbone's research seeks to elucidate the biophysical mechanisms governing the activity and interaction of AMPAR-TARP complexes, and to investigate the role of AMPARs and TARPs in synaptic plasticity and disease. In August 2017 Anna Carbone will move to Hamburg to work as a scientist at Evotec.
Tamar Dugladze
Tamar Dugladze's research focuses on the mechanisms of signal flow in the nervous system, and the relevance of these mechanisms in the genesis of seizures and epilepsy.
2010
Tatiana Korotkova
Tatiana Korotkova's project focuses on the interactions between subgroups of hypothalamic neurons as well as the regulation of hypothalamic circuits by cortical afferents. In 2017 Dr. Korotkova moved to Cologne to head a research group at the MPI Institute for Biology of Ageing.
Veronica Witte
Veronica Witte's project investigates whether caloric restriction or other dietary modifications can improve cognitive functions and surrogate markers of beginning cognitive decline in healthy elderly subjects, and in patients with mild cognitive impairment (MCI). In 2014 Dr. Witte moved to Leipzig to head a research group at the MPI for Human Cognitive and Brain Sciences.
 
 
NeuroCure Visiting Fellows and Scientists:
The aim of NeuroCure's Visiting Fellows and Scientists funding program is to integrate renowned foreign scientists into the Berlin research landscape to further strengthen the international profile of the universities and research facilities, and to foster collaborative projects with NeuroCure Principal Investigators.
Please find more information here.