Through, for example, start-up financing for highly innovative projects and clinical studies, NeuroCure can react flexibly and quickly to new trends in the neurosciences. The granting of funds is carried out efficiently and transparently based on award procedures that have been worked out according to high Quality standards.
The Cluster aims to support collaborations between two NeuroCure research groups and offers funding for initiating collaborative research projects that will lead to significant preliminary data and ultimately enable grant applications to national and international funding agencies.
Britta Eickholt and Christian Rosenmund
Analyses of PI3K/mT or signaling as common defect underlying neurodevelopmental disorders
Sampathkumar, C., Y. J. Wu, M. Vadhvani, T. Trimbuch, B. Eickholt, and C. Rosenmund. "Loss of Mecp2 Disrupts Cell Autonomous and Autocrine Bdnf Signaling in Mouse Glutamatergic Neurons." Elife 5 (Oct 26 2016). http://dx.doi.org/10.7554/eLife.19374.
“Common functions of PTEN and MeCP2, two genes affected in ASD” funded by the Simons Foundation (USA).
Matthias Endres and Helmut Kettenmann
Functional muscarinic acetycholine receptors control microglia/brain macrophage properties after stroke
Pannell, M., M. A. Meier, F. Szulzewsky, V. Matyash, M. Endres, G. Kronenberg, V. Prinz, S. Waiczies, S. A. Wolf, and H. Kettenmann. "The Subpopulation of Microglia Expressing Functional Muscarinic Acetylcholine Receptors Expands in Stroke and Alzheimer's Disease." Brain Struct Funct 221, no. 2 (Mar 2016): 1157-72. http://dx.doi.org/10.1007/s00429-014-0962-y.
James Poulet and Andrew Plested
Optical silencing and recording of neurotransmission in the mammalian brain
“Excitatory synapses: from structural biology to optical control” funded by the DFG (Heisenberg Professorship)
“Optical control of glutamate receptors using genetically encoded unnatural amino acids” funded by the DFG (PL619)
“Optical control and report of synaptic transmission”, Wellcome Trust Senior Fellowship (UK), declined
Josef Priller and Erich Wanker
Reinforcement learning in frontotemporal dementia and in Drosophila models of TDP-43 proteinopathy
Lorenz, C., P. Lesimple, R. Bukowiecki, A. Zink, G. Inak, B. Mlody, M. Singh, M. Semtner, N. Mah, K. Aure, M. Leong, O. Zabiegalov, E. M. Lyras, V. Pfiffer, B. Fauler, J. Eichhorst, B. Wiesner, N. Huebner, J. Priller, T. Mielke, D. Meierhofer, Z. Izsvak, J. C. Meier, F. Bouillaud, J. Adjaye, M. Schuelke, E. E. Wanker, A. Lombes, and A. Prigione. "Human Ipsc-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological Mtdna Disorders." Cell Stem Cell 20, no. 5 (May 04 2017): 659-74 e9. http://dx.doi.org/10.1016/j.stem.2016.12.013.
Vopel, T., K. Bravo-Rodriguez, S. Mittal, S. Vachharajani, D. Gnutt, A. Sharma, A. Steinhof, O. Fatoba, G. Ellrichmann, M. Nshanian, C. Heid, J. A. Loo, F. G. Klarner, T. Schrader, G. Bitan, E. E. Wanker, S. Ebbinghaus, and E. Sanchez-Garcia. "Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer Clr01." J Am Chem Soc 139, no. 16 (Apr 26 2017): 5640-43.http://dx.doi.org/10.1021/jacs.6b11039.
Sin, O., T. de Jong, A. Mata-Cabana, M. Kudron, M. A. Zaini, F. A. Aprile, R. I. Seinstra, E. Stroo, R. W. Prins, C. N. Martineau, H. H. Wang, W. Hogewerf, A. Steinhof, E. E. Wanker, M. Vendruscolo, C. F. Calkhoven, V. Reinke, V. Guryev, and E. A. Nollen. "Identification of an Rna Polymerase Iii Regulator Linked to Disease-Associated Protein Aggregation." Mol Cell 65, no. 6 (Mar 16 2017): 1096-108 e6. http://dx.doi.org/10.1016/j.molcel.2017.02.022.
Nickchen, K., R. Boehme, M. Del Mar Amador, T. D. Halbig, K. Dehnicke, P. Panneck, J. Behr, K. Prass, A. Heinz, L. Deserno, F. Schlagenhauf, and J. Priller. "Reversal Learning Reveals Cognitive Deficits and Altered Prediction Error Encoding in the Ventral Striatum in Huntington's Disease." Brain Imaging Behav (Dec 05 2016). http://dx.doi.org/10.1007/s11682-016-9660-0.
Zografos, L., J. Tang, F. Hesse, E. E. Wanker, K. W. Li, A. B. Smit, R. W. Davies, and J. D. Armstrong. "Functional Characterisation of Human Synaptic Genes Expressed in the Drosophila Brain." Biol Open 5, no. 5 (May 15 2016): 662-7. http://dx.doi.org/10.1242/bio.016261.
Stroedicke, M., Y. Bounab, N. Strempel, K. Klockmeier, S. Yigit, R. P. Friedrich, G. Chaurasia, S. Li, F. Hesse, S. P. Riechers, J. Russ, C. Nicoletti, A. Boeddrich, T. Wiglenda, C. Haenig, S. Schnoegl, D. Fournier, R. K. Graham, M. R. Hayden, S. Sigrist, G. P. Bates, J. Priller, M. A. Andrade-Navarro, M. E. Futschik, and E. E. Wanker. "Systematic Interaction Network Filtering Identifies Crmp1 as a Novel Suppressor of Huntingtin Misfolding and Neurotoxicity." Genome Res 25, no. 5 (May 2015): 701-13. http://dx.doi.org/10.1101/gr.182444.114.
“Effects of Huntingtin Seeding on Neurodegeneration, Behavior and Life Span in an Inducible Drosophila Model of Huntington’s Disease” funded by the Cure Huntington’s Disease Initiative Foundation (USA)
Markus Schülke-Gerstenfeld and Stephan Sigrist
Discovery of novel disease genes involved in the development of the peripheral nervous system and their functional evaluation in the Drosophila model
Knierim, E., H. Hirata, N. I. Wolf, S. Morales-Gonzalez, G. Schottmann, Y. Tanaka, S. Rudnik-Schoneborn, M. Orgeur, K. Zerres, S. Vogt, A. van Riesen, E. Gill, F. Seifert, A. Zwirner, J. Kirschner, H. H. Goebel, C. Hubner, S. Stricker, D. Meierhofer, W. Stenzel, and M. Schuelke. "Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures." Am J Hum Genet 98, no. 3 (Mar 03 2016): 473-89. http://dx.doi.org/10.1016/j.ajhg.2016.01.006.
Straussberg, R., G. Schottmann, M. Sadeh, E. Gill, F. Seifert, A. Halevy, K. Qassem, J. Rendu, P. F. van der Ven, W. Stenzel, and M. Schuelke. "Kyphoscoliosis Peptidase (Ky) Mutation Causes a Novel Congenital Myopathy with Core Targetoid Defects." Acta Neuropathol 132, no. 3 (Sep 2016): 475-8. http://dx.doi.org/10.1007/s00401-016-1602-9.
Imre Vida and Dietmar Schmitz
Spatial organization of inhibitory microcircuit of the grid cell navigation system in the rat entorhinal cortex
The aim of NeuroCure's Visiting Fellows and Scientists funding program is to integrate renowned foreign scientists into the Berlin research landscape to further strengthen the international profile of the universities and research facilities, and to foster collaborative projects with NeuroCure Principal Investigators.