New Junior Groups
As part of our commitment to provide opportunities for early career researchers, NeuroCure will establish several new junior research groups in cooperation with our partner institutions during the current funding period.
New groups established so far include:
Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE)
The Neurocircuit Development and Function (NDF) group is engaged in understanding how neural circuits involved in the control of energy homeostasis develop and function within complex networks in the brain. Specifically, the team wants to understand how maternal nutrition and altered maternal metabolism can negatively impact the proper formation and function of these brain circuits, resulting in the potential for an earlier onset of brain-related diseases. This work is performed using rodent model systems to target the function of specific neuronal systems to better understand their role in metabolism and behavior.
Berlin Institute of Health (BIH)
The Computational Neurology group develops theory- and data-driven methods to better monitor, predict and prevent health deteriorations in epilepsy, intensive care and other neurology settings. Our approach utilizes multimodal time series data over the health-disease continuum, including wearables, in-hospital neuromonitoring, video and EEG. We are exploring the relevance of dynamical systems frameworks for system function in neurology, among them the critical brain hypothesis. Our work is motivated by a more quantitative, data-driven understanding of health and disease that will ultimately afford more proactive treatment options.
Humboldt Universität zu Berlin (HU)
The Optobiology group combines biochemical, biophysical, molecular biological and bioinformatic methods with advanced imaging techniques to tackle questions dealing with different aspects of neuronal cell biology. Current projects explore roles of the microtubule and actin cytoskeleton as well as intracellular organelle trafficking in controlling the formation, stability and plasticity of synaptic contacts in health and disease.
German Center for Neurodegenerative Diseases (DZNE)
The Cellular Circuits of Memory group is focused on understanding how neuronal circuits in the hippocampal-associated brain regions are altered in normal aging as well as in memory pathologies. We use electrophysiological methods to investigate brain oscillations and single cell activity in animals while they perform different behavioral tasks. Taking advantage of transgenic mouse lines and genetic manipulations with viral vectors we try to understand how different cell types are involved in the formation of short and long-lasting memories. Our work is aimed at identifying altered neuronal circuits with the potential for manipulation in order to ameliorate or restore memory impairments in neurodegenerative diseases such as Alzheimer’s disease.
Dr. Noa Lipstein
Max-Planck-Institut für Experimentelle Medizin, Germany
Expected starting date: early 2021