Brain Stimulation: Brain stimulation and intensive training in the rehabilitation of chronic motor paresis and chronic aphasia following stroke

Study Description:
In these projects, patients who have suffered paralysis (motor paresis) or a language disorder (aphasia) following stroke were examined through intensive physiotherapeutic training as well as a combination of physiotherapeutic training and transcranial direct current stimulation or through highly intensive individually customized naming training as well as a combination of intensive naming training and transcranial direct current stimulation. At the same time, the underlying mechanisms were recorded through structural and functional imaging techniques (as well as single-pulse transcranial magnet stimulation).

Principle Investigator: Prof. Dr. Agnes Flöel (WG Cognitive Neurology, NCRC, CSB, Neurology CCM)

Registration: This study is registered int the database clinicaltrials.gov (NCT01221779).

Course of the study: 05/2012 - 02/2015

Publication:
Breitenstein, C., T. Grewe, A. Floel, W. Ziegler, L. Springer, P. Martus, W. Huber, K. Willmes, E. B. Ringelstein, K. G. Haeusler, S. Abel, R. Glindemann, F. Domahs, F. Regenbrecht, K. J. Schlenck, M. Thomas, H. Obrig, E. de Langen, R. Rocker, F. Wigbers, C. Ruhmkorf, I. Hempen, J. List, A. Baumgaertner, and Fcet Ec study group. "Intensive Speech and Language Therapy in Patients with Chronic Aphasia after Stroke: A Randomised, Open-Label, Blinded-Endpoint, Controlled Trial in a Health-Care Setting." Lancet 389, no. 10078 (Apr 15 2017): 1528-38. http://dx.doi.org/10.1016/S0140-6736(17)30067-3. Link