Glucose tolerance: Training – beneficial for vessels and nerve cells

Study Description:
Previous findings suggest that exercise has a positive effect on vessels supplying the brain. Moreover, it has been shown that exercise can improve existing conditions of impaired glucose tolerance or diabetes mellitus, even in the absence of accompanying weight loss.

In this mono-center, prospective, single blind, randomized, placebo-controlled study, we investigated the effects of “Nordic Walking” on memory capacity and vascular functions in elderly people. Our results made it possible to develop specific exercise interventions for this group of elderly individuals, and possibly even pharmaceutical “exercise mimetics” (e.g. neurotrophic factors that can be injected).

Principle Investigator: Prof. Dr. Agnes Flöel (WG Cognitive Neurology, NCRC, CSB, Neurology CCM)

Registration: This study is registered in the database clinicaltrials.gov (NCT01219231).

Course of the study: 01/2011 - 01/2015

Publication:
Prehn, K., A. Lesemann, G. Krey, A. V. Witte, T. Kobe, U. Grittner, and A. Floel. "Using Resting-State Fmri to Assess the Effect of Aerobic Exercise on Functional Connectivity of the Dlpfc in Older Overweight Adults." Brain Cogn (Aug 23 2017). Link