Mechanisms of immune regulation by IVIG
This study investigated the effect of immunoglobulins (antibodies) on cellular components of the immune system. We were above all interested to what extent the administering of immunoglobulins changes the function of certain immune cells.
Principle Investigator: Dr. Hendrik Harms (WG Cerebrovascular Diseases, NCRC, Neurology CCM)
Course of the study: 02/2015 - 02/2016
Klehmet, J., J. Goehler, L. Ulm, S. Kohler, C. Meisel, A. Meisel, and H. Harms. "Effective Treatment with Intravenous Immunoglobulins Reduces Autoreactive T-Cell Response in Patients with Cidp." J Neurol Neurosurg Psychiatry 86, no. 6 (Jun 2015): 686-91. http://dx.doi.org/10.1136/jnnp-2014-307708. Link
Klehmet, J., M. Staudt, L. Ulm, N. Unterwalder, A. Meisel, and C. Meisel. "Circulating Lymphocyte and T Memory Subsets in Glucocorticosteroid Versus Ivig Treated Patients with Cidp." J Neuroimmunol 283 (Jun 15 2015): 17-22. http://dx.doi.org/10.1016/j.jneuroim.2015.03.023. Link