PREDICT: Prediction of stroke-associated pneumonias

Study Description:
PREDICT was an observation study on the predictive power of clinical parameters and bio-markers regarding stroke-associated pneumonia. This was intended to allow targeted prevention of this life-threatening complication in stroke patients.

Principle Investigator: Prof. Dr. Andreas Meisel (WG Cerebrovascular Diseases, NCRC, CSB, Neurology CCM)

Registration: This study is registered in the database (NCT01079728).

Course of the study: 02/2010 - 04/2013

Hoffmann, S., H. Harms, L. Ulm, D. G. Nabavi, B. M. Mackert, I. Schmehl, G. J. Jungehulsing, J. Montaner, A. Bustamante, M. Hermans, F. Hamilton, J. Gohler, U. Malzahn, C. Malsch, P. U. Heuschmann, C. Meisel, A. Meisel, and Predict Investigators. "Stroke-Induced Immunodepression and Dysphagia Independently Predict Stroke-Associated Pneumonia - the Predict Study." J Cereb Blood Flow Metab (Jan 01 2016): 271678X16671964. Link

Hotter, B., S. Hoffmann, L. Ulm, C. Meisel, J. B. Fiebach, and A. Meisel. "Il-6 Plasma Levels Correlate with Cerebral Perfusion Deficits and Infarct Sizes in Stroke Patients without Associated Infections." Front Neurol 10 (2019): 83. Link

Hotter, B., S. Hoffmann, L. Ulm, J. Montaner, A. Bustamante, C. Meisel, and A. Meisel. "Inflammatory and Stress Markers Predicting Pneumonia, Outcome, and Etiology in Patients with Stroke: Biomarkers for Predicting Pneumonia, Functional Outcome, and Death after Stroke." Neurol Neuroimmunol Neuroinflamm 7, no. 3 (May 2020). LInk

Hotter, B., S. Hoffmann, L. Ulm, C. Meisel, A. Bustamante, J. Montaner, M. Katan, C. J. Smith, and A. Meisel. "External Validation of Five Scores to Predict Stroke-Associated Pneumonia and the Role of Selected Blood Biomarkers." Stroke 52, no. 1 (Jan 2021): 325-30. Link

Mengel, A., L. Ulm, B. Hotter, H. Harms, S. K. Piper, U. Grittner, J. Montaner, C. Meisel, A. Meisel, and S. Hoffmann. "Biomarkers of Immune Capacity, Infection and Inflammation Are Associated with Poor Outcome and Mortality after Stroke - the Predict Study." BMC Neurol 19, no. 1 (Jul 3 2019): 148. Link

Winek, K., S. Lobentanzer, B. Nadorp, S. Dubnov, C. Dames, S. Jagdmann, G. Moshitzky, B. Hotter, C. Meisel, D. S. Greenberg, S. Shifman, J. Klein, S. Shenhar-Tsarfaty, A. Meisel, and H. Soreq. "Transfer Rna Fragments Replace Microrna Regulators of the Cholinergic Poststroke Immune Blockade." Proc Natl Acad Sci U S A 117, no. 51 (Dec 22 2020): 32606-16. Link