SUPREMES: Sunphenon (epigallocatechin-gallate) in progressive forms of multiple sclerosis

Study Description:
The SUPREMES study investigated the effectiveness of a extract gained from green tee (epigallocatechin gallat, EGCG) on various MRT parameters, disability progression and brain performance in MS patients. This is also a randomized, placebo-controlled, double-blind study. This study included patients with primary or secondary chronic progressive MS. The running time was two and a half years per patient.

Principle Investigator: Prof. Dr. Friedemann Paul (WG Clinical Neuroimmunology, NCRC, ECRC)

Course of the study: 11/2008 - 02/2016

Klumbies, K., R. Rust, J. Dorr, F. Konietschke, F. Paul, J. Bellmann-Strobl, A. U. Brandt, and H. G. Zimmermann. "Retinal Thickness Analysis in Progressive Multiple Sclerosis Patients Treated with Epigallocatechin Gallate: Optical Coherence Tomography Results from the Supremes Study." Front Neurol 12 (2021): 615790.

Rust, R., C. Chien, M. Scheel, A. U. Brandt, J. Dorr, J. Wuerfel, K. Klumbies, H. Zimmermann, M. Lorenz, K. D. Wernecke, J. Bellmann-Strobl, and F. Paul. "Epigallocatechin Gallate in Progressive Ms: A Randomized, Placebo-Controlled Trial." Neurol Neuroimmunol Neuroinflamm 8, no. 3 (May 2021).