Locato: Transcranial direct current stimulation and intensive cognitive training in patients with mild cognitive impairment

Study Description:
The aim of the project  was to study the efficacy and the underlying mechanisms of a new approach in the treatment of patients with (amnestic) mild cognitive impairments. The treatment combined an intensive training of a visual-spatial task lasting several days and simultaneous brain stimulation. Structural and functional cerebral correlates of behavioral changes were measured using magnetic resonance tomography (MRT).

Principle Investigator: Prof. Dr. med. Agnes Flöel (WG Cognitive Neurology, NCRC, Neurology CCM)

Registration: The study is registered in the database clinicaltrials.gov (NCT02110043).

Course of the study: 04/2014 - 09/2017

Antonenko, D., N. Kulzow, M. E. Cesarz, K. Schindler, U. Grittner, and A. Floel. "Hippocampal Pathway Plasticity Is Associated with the Ability to Form Novel Memories in Older Adults." Front Aging Neurosci 8 (2016): 61. Link

Antonenko, D., N. Kulzow, A. Sousa, K. Prehn, U. Grittner, and A. Floel. "Neuronal and Behavioral Effects of Multi-Day Brain Stimulation and Memory Training." Neurobiol Aging 61 (Jan 2018): 245-54. Link

de Sousa, A. V. C., U. Grittner, D. Rujescu, N. Kulzow, and A. Floel. "Impact of 3-Day Combined Anodal Transcranial Direct Current Stimulation-Visuospatial Training on Object-Location Memory in Healthy Older Adults and Patients with Mild Cognitive Impairment." J Alzheimers Dis 75, no. 1 (2020): 223-44. Link

Kulzow, N., A. V. Cavalcanti de Sousa, M. Cesarz, J. M. Hanke, A. Gunsberg, S. Harder, S. Koblitz, U. Grittner, and A. Floel. "No Effects of Non-Invasive Brain Stimulation on Multiple Sessions of Object-Location-Memory Training in Healthy Older Adults." Front Neurosci 11 (2017): 746. Link

Kulzow, N., L. Kerti, V. A. Witte, U. Kopp, C. Breitenstein, and A. Floel. "An Object Location Memory Paradigm for Older Adults with and without Mild Cognitive Impairment." J Neurosci Methods 237 (Nov 30 2014): 16-25. Link