Locato: Transcranial direct current stimulation and intensive cognitive training in patients with mild cognitive impairment

Study Description:
The aim of the project  was to study the efficacy and the underlying mechanisms of a new approach in the treatment of patients with (amnestic) mild cognitive impairments. The treatment combined an intensive training of a visual-spatial task lasting several days and simultaneous brain stimulation. Structural and functional cerebral correlates of behavioral changes were measured using magnetic resonance tomography (MRT).

Principle Investigator: Prof. Dr. med. Agnes Flöel (WG Cognitive Neurology, NCRC, Neurology CCM)

Registration: The study is registered in the database clinicaltrials.gov (NCT02110043).

Course of the study: 04/2014 - 09/2017

Publications: 
Antonenko, D., N. Kulzow, M. E. Cesarz, K. Schindler, U. Grittner, and A. Floel. "Hippocampal Pathway Plasticity Is Associated with the Ability to Form Novel Memories in Older Adults." Front Aging Neurosci 8 (2016): 61. Link

Antonenko, D., N. Kulzow, A. Sousa, K. Prehn, U. Grittner, and A. Floel. "Neuronal and Behavioral Effects of Multi-Day Brain Stimulation and Memory Training." Neurobiol Aging 61 (Jan 2018): 245-54. Link

de Sousa, A. V. C., U. Grittner, D. Rujescu, N. Kulzow, and A. Floel. "Impact of 3-Day Combined Anodal Transcranial Direct Current Stimulation-Visuospatial Training on Object-Location Memory in Healthy Older Adults and Patients with Mild Cognitive Impairment." J Alzheimers Dis 75, no. 1 (2020): 223-44. Link

Kulzow, N., A. V. Cavalcanti de Sousa, M. Cesarz, J. M. Hanke, A. Gunsberg, S. Harder, S. Koblitz, U. Grittner, and A. Floel. "No Effects of Non-Invasive Brain Stimulation on Multiple Sessions of Object-Location-Memory Training in Healthy Older Adults." Front Neurosci 11 (2017): 746. Link

Kulzow, N., L. Kerti, V. A. Witte, U. Kopp, C. Breitenstein, and A. Floel. "An Object Location Memory Paradigm for Older Adults with and without Mild Cognitive Impairment." J Neurosci Methods 237 (Nov 30 2014): 16-25. Link