CIS: Clinically isolated syndrome and newly diagnosed multiple sclerosis: diagnostic, prognostic and therapy-response markers

Study Description:
This progression investigation is oriented towards patients who have only been suffering from multiple sclerosis for a short period of time or who have been diagnosed with so-called "clinically isolated syndrome" (CIS). This is an observational study which is intended to help the understanding of the disease in its earlier stages and to develop markers for progression and prognosis. At regular intervals, the study participants receive, among other things, a neurological examination, an MRT examination and optical coherence tomography.

Principle Investigator: Prof. Dr. Friedemann Paul (WG Clinical Neuroimmunology, NCRC, ECRC)

Registration: The study is registered in clinicaltrials.gov (NCT01371071)

Course of the study: 11/2011

Publications:
Cooper, G., C. Chien, H. Zimmermann, J. Bellmann-Strobl, K. Ruprecht, J. Kuchling, S. Asseyer, A. U. Brandt, M. Scheel, C. Finke, and F. Paul."Longitudinal Analysis of T1w/T2w Ratio in Patients with Multiple Sclerosis from First Clinical Presentation."Mult Scler 27, no. 14 (Dec 2021): 2180-90.
https://dx.doi.org/10.1177/13524585211003479. Link.

Derkow, K., J. M. Bauer, M. Hecker, B. K. Paap, M. Thamilarasan, D. Koczan, E. Schott, K. Deuschle, J. Bellmann-Strobl, F. Paul, U. K. Zettl, K. Ruprecht, and S. Lehnardt. "Multiple Sclerosis: Modulation of Toll-Like Receptor (Tlr) Expression by Interferon-Beta Includes Upregulation of Tlr7 in Plasmacytoid Dendritic Cells." PLoS One 8, no. 8 (2013): e70626. http://dx.doi.org/10.1371/journal.pone.0070626. Link.

Schliesseit, J., F. C. Oertel, G. Cooper, A. U. Brandt, and J. Bellmann-Strobl. "Longitudinal Analysis of Primary and Secondary Factors Related to Fatigue in Multiple Sclerosis." Acta Neurol Belg (Nov 13 2020). https://dx.doi.org/10.1007/s13760-020-01545-6. Link.

Weygandt, M., L. Meyer-Arndt, J. R. Behrens, K. Wakonig, J. Bellmann-Strobl, K. Ritter, M. Scheel, A. U. Brandt, C. Labadie, S. Hetzer, S. M. Gold, F. Paul, and J. D. Haynes. "Stress-Induced Brain Activity, Brain Atrophy, and Clinical Disability in Multiple Sclerosis." Proc Natl Acad Sci U S A 113, no. 47 (Nov 22 2016): 13444-49. http://dx.doi.org/10.1073/pnas.1605829113. Link.