NeuroMET2: metrology and innovation for the early diagnosis and accurate stratification of patients with neurodegenerative diseases

Study Description:
This study aims to improve the diagnosis of dementia caused by Alzheimer's, especially in its earliest stages, so the course of the disease can be predicted and characterized more precisely.
The following methods of measurement are applied:
- magnetic resonance spectroscopy (MRS)
- functional and structural magnetic resonance imaging (MRT)
- blood tests and analysis
- voluntary spinal fluid tests
- neuropsychological tests
Both common and new measurement parameters (biomarkers) are also analyzed, and after 12 months, a follow-up examination is performed. Participants in the study receive a compensation of 40€, and their examination results are passed along to their doctor.
Detailed information about the study can also be found here.

Principle Investigator: Prof. Dr. med. Matthias Endres (Department of Neurology, Charité Campus Mitte)

Co-director: Prof. Dr. med. Agnes Flöel (University of Medicine, Universitätsmedizin-Greifswald)

Study center: Charité - Universitätsmedizin Berlin; Clinic and Polyclinic for Neurology in cooperation with the NeuroCure Clinical Research Center (NCRC), Campus Mitte, Charitéplatz 1, 10117 Berlin (Tel. 030 / 450 560 280, Fax 030 / 450 7 560 280)

Course of the study: 12.11.2019 - 29.06.2022

Project partners:
- Physikalisch-Technische Bundesanstalt (PTB), 10587 Berlin, Germany
- Universitätsmedizin Greifswald, 17475 Greifswald, Germany
- LGC Limited (LGC), Middlesex TW11 0LY, United Kingdom
- Centre Hospitalier Universitaire de Montpellier (CHU Mpt), Biochimie - Protéomique Clinique, 34295 Montpellier, France
- Laboratoire national de métrologie d'essais (LNE), 75015 Paris, France
- RISE Research Institutes of Sweden (RISE), 41756 Gothenburg, Sweden
- Modus Outcome, Letchworth Garden City SG6 4ET United Kingdom
- Vrije Universiteit Medical Center (VUmc), 1081 HV Amsterdam, Netherlands

Funding: EURAMET e.V. and European Metrology Program for Innovation and Research (EMPIR) - Health Call 2018.

Project number: 18HLT09

Contact: If you are interested in participating or if you have any questions regarding the NeuroMET2 Alzheimer's study, please contact the study team at (030-450 560 280). You can also send us an e-mail any time: (NeuroMET2(at)
We would be happy to send you the official study brochure with any further information. Thank you very much for your interest!
The NeuroMET2 study is a continuation of the NeuroMET project (2016-2019) which was also carried out at the Charité in the NeuroCure Clinical Research Center. NeuroMET2 works with the existing cohort, following the individual changes of each subject. 

Göschel L, Köbe T, Wang H, Aydin S, Ittermann B, Fillmer A, Flöel A. Myoinositol Concentration and Volume of the Posterior Cingulate Cortex across the Ad Continuum Measured by 7t Mri/Mrs. Vol. 15. Alzheimer’s & Dementia: Wiley, 2019.  Link.

Melin J, Cano SJ, Flöel A, Göschel L, Pendrill LR, EMPIR NeuroMET, NeuroMET2 consortiums. More Than a Memory Test: A New Metric Linking Blocks, Numbers, and Words. Vol. 17. Alzheimer’s & Dementia: Wiley, 2021. Link.

Melin J, Cano SJ, Flöel A, Göschel L, Pendrill LR. Construct Specification Equations: ‘Recipes’ for Certified Reference Materials in Cognitive Measurement. Translated by International Measurement Confederation. Vol. 18. Measurement: Sensors. Edited by K. Grattan. Online: Elsevier Ltd., 2021. Link.

Melin J, Cano SJ, Göschel L, Fillmer A, Lehmann S, Hirtz C, Flöel A, Pendrill LR. Metrological References for Person Ability in Memory Tests. Translated by International Measurement Confederation. Vol. 18. Measurement: Sensors. Edited by K. Grattan. Online: Elsevier Ltd., 2021. Link.

Quaglia, Milena, Stefan Cano, Ariane Fillmer, Agnes Flöel, Chiara Giangrande, Laura Göschel, Sylvain Lehmann, Jeanette Melin, and Charlotte E. Teunissen. "The Neuromet Project: Metrology and Innovation for Early Diagnosis and Accurate Stratification of Patients with Neurodegenerative Diseases." Alzheimer's & Dementia 17, no. S5 (2021): e053655. Link.