VIMS Study: Follow-up examination of visual parameters for the creation of a database (neuro-ophthalmologic register) in patients with multiple sclerosis versus healthy subjects

Multiple Sclerosis can cause characteristic changes in the retina of the eye. With so-called optical coherence tomography (OCT) - a well-established technique for diagnosing eye diseases - the structure of the retina can be easily measured. In this observational study, we would like to examine whether, through the use of OCT, a loss of nerve cells and fibers can be demonstrated, and whether over several years measurable changes can be detected which reflect disease activity, disease progression and disease severity in patients with MS. To answer these questions, measurable changes in the retina will be collected and compared with the extent of the patient’s physical disabilities, cognitive limitations, changes in MRI, quality of life, and the concentration of certain substances in the blood. Advantages for study participants include regular clinical examinations and the possibility of follow-up. Participation is open to both male and female multiple sclerosis patients (RRMS, PPMS, SPMS), as well as to healthy subjects aged between 20-69 years. Examinations will take place annually over a ten-year period.

Study Director: Prof. Dr. Friedemann Paul (WG Neuroimmunology, NCRC)


Schliesseit, J., F. C. Oertel, G. Cooper, A. U. Brandt, and J. Bellmann-Strobl. "Longitudinal Analysis of Primary and Secondary Factors Related to Fatigue in Multiple Sclerosis." Acta Neurol Belg (Nov 13 2020). Link