Publications 2020

Ahmadi M, Laumeier I, Ihl T, Steinicke M, Ferse C, Endres M, Grau A, Hastrup S, Poppert H, Palm F, Schoene M, Seifert CL, Kandil FI, Weber JE, von Weitzel-Mudersbach P, Wimmer MLJ, Algra A, Amarenco P, Greving JP, Busse O, Kohler F, Marx P, Audebert HJ. A support programme for secondary prevention in patients with transient ischaemic attack and minor stroke (INSPiRE-TMS): an open-label, randomised controlled trialLancet Neurol 2020, 19. http://dx.doi.org/10.1016/S1474-4422(19)30369-2.

Bahr LS, Bock M, Liebscher D, Bellmann-Strobl J, Franz L, Pruss A, Schumann D, Piper SK, Kessler CS, Steckhan N, Michalsen A, Paul F, Mahler A. Ketogenic diet and fasting diet as Nutritional Approaches in Multiple Sclerosis (NAMS): protocol of a randomized controlled studyTrials 2020, 21. http://dx.doi.org/10.1186/s13063-019-3928-9.

Barbe MT, Tonder L, Krack P, Debu B, Schupbach M, Paschen S, Dembek TA, Kuhn AA, Fraix V, Brefel-Courbon C, Wojtecki L, Maltete D, Damier P, Sixel-Doring F, Weiss D, Pinsker M, Witjas T, Thobois S, Schade-Brittinger C, Rau J, Houeto JL, Hartmann A, Timmermann L, Schnitzler A, Stoker V, Vidailhet M, Deuschl G; EARLYSTIM study group. Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease With Early Motor ComplicationsMov Disord 2020, 35. http://dx.doi.org/10.1002/mds.27892.

Bertovic I, Kurelic R, Milosevic I, Bender M, Krauss M, Haucke V, Jurak Begonja A. Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomesJ Thromb Haemost 2020. http://dx.doi.org/10.1111/jth.14764.

Boge K, Karnouk C, Hahn E, Schneider F, Habel U, Banaschewski T, Meyer-Lindenberg A, Salize HJ, Kamp-Becker I, Padberg F, Hasan A, Falkai P, Rapp MA, Plener PL, Stamm T, Elnahrawy N, Lieb K, Heinz A, Bajbouj M. Mental health in refugees and asylum seekers (MEHIRA): study design and methodology of a prospective multicentre randomized controlled trail investigating the effects of a stepped and collaborative care modelEur Arch Psychiatry Clin Neurosci 2020, 270. http://dx.doi.org/10.1007/s00406-019-00991-5.

Bossier H, Roels SP, Seurinck R, Banaschewski T, Barker GJ, Bokde ALW, Quinlan EB, Desrivieres S, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Artiges E, Nees F, Orfanos DP, Poustka L, Frohner Dipl-Psych JH, Smolka MN, Walter H, Whelan R, Schumann G, Moerkerke B; IMAGEN Consortium. The empirical replicability of task-based fMRI as a function of sample sizeNeuroimage 2020. http://dx.doi.org/10.1016/j.neuroimage.2020.116601.

Bratovic M, Fonfara I, Chylinski K, Galvez EJC, Sullivan TJ, Boerno S, Timmermann B, Boettcher M, Charpentier E. Bridge helix arginines play a critical role in Cas9 sensitivity to mismatchesNat Chem Biol 2020. http://dx.doi.org/10.1038/s41589-020-0490-4.

Broersen LHA, Stengl H, Nolte CH, Westermann D, Endres M, Siegerink B, Scheitz JF. Association Between High-Sensitivity Cardiac Troponin and Risk of Stroke in 96 702 Individuals: A Meta-AnalysisStroke 2020. http://dx.doi.org/10.1161/STROKEAHA.119.028323.

Burggraaff J, Dorn J, D'Souza M, Morrison C, Kamm CP, Kontschieder P, Tewarie P, Steinheimer S, Sellen A, Dahlke F, Kappos L, Uitdehaag B. Video-Based Pairwise Comparison: Enabling the Development of Automated Rating of Motor Dysfunction in Multiple SclerosisArch Phys Med Rehabil 2020, 101. http://dx.doi.org/10.1016/j.apmr.2019.07.016.

Burkner PC, Charpentier E. Modelling monotonic effects of ordinal predictors in Bayesian regression modelsBr J Math Stat Psychol 2020. http://dx.doi.org/10.1111/bmsp.12195.

Cheng B, Boutitie F, Nickel A, Wouters A, Cho TH, Ebinger M, Endres M, Fiebach JB, Fiehler J, Galinovic I, Puig J, Thijs V, Lemmens R, Muir KW, Nighoghossian N, Pedraza S, Simonsen CZ, Gerloff C, Thomalla G, investigators W-U, administrative staff are as f. Quantitative Signal Intensity in Fluid-Attenuated Inversion Recovery and Treatment Effect in the WAKE-UP TrialStroke 2020, 51. http://dx.doi.org/10.1161/STROKEAHA.119.027390.

Chien C, Juenger V, Scheel M, Brandt AU, Paul F. Considerations for Mean Upper Cervical Cord Area Implementation in a Longitudinal MRI Setting: Methods, Interrater Reliability, and MRI Quality ControlAJNR Am J Neuroradiol 2020. http://dx.doi.org/10.3174/ajnr.A6394.

Cury C, Scelsi MA, Toro R, Frouin V, Artiges E, Grigis A, Heinz A, Lemaitre H, Martinot JL, Poline JB, Smolka MN, Walter H, Schumann G, Altmann A, Colliot O; IMAGEN Consortium. Genome wide association study of incomplete hippocampal inversion in adolescentsPLoS One 2020, 15. http://dx.doi.org/10.1371/journal.pone.0227355.

Deserno L, Boehme R, Mathys C, Katthagen T, Kaminski J, Stephan KE, Heinz A, Schlagenhauf F. Volatility Estimates Increase Choice Switching and Relate to Prefrontal Activity in SchizophreniaBiol Psychiatry Cogn Neurosci Neuroimaging 2020, 5. http://dx.doi.org/10.1016/j.bpsc.2019.10.007.

Dirnagl U. Resolving the Tension Between Exploration and Confirmation in Preclinical Biomedical ResearchHandb Exp Pharmacol 2020, 257. http://dx.doi.org/10.1007/164_2019_278.

Drimalla H, Scheffer T, Landwehr N, Baskow I, Roepke S, Behnia B, Dziobek I. Towards the automatic detection of social biomarkers in autism spectrum disorder: introducing the simulated interaction task (SIT)NPJ Digit Med 2020, 3. http://dx.doi.org/10.1038/s41746-020-0227-5.

Dusek P, Mekle R, Skowronska M, Acosta-Cabronero J, Huelnhagen T, Robinson SD, Schubert F, Deschauer M, Els A, Ittermann B, Schottmann G, Madai VI, Paul F, Klopstock T, Kmiec T, Niendorf T, Wuerfel J, Schneider SA. Brain iron and metabolic abnormalities in C19orf12 mutation carriers: A 7.0 tesla MRI study in mitochondrial membrane protein-associated neurodegenerationMov Disord 2020, 35. http://dx.doi.org/10.1002/mds.27827.

Eede P, Obst J, Benke E, Yvon-Durocher G, Richard BC, Gimber N, Schmoranzer J, Boddrich A, Wanker EE, Prokop S, Heppner FL. Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like miceEMBO Rep 2020. http://dx.doi.org/10.15252/embr.201948530.

Falck J, Bruns C, Hoffmann-Conaway S, Straub I, Plautz EJ, Orlando M, Munawar H, Rivalan M, Winter Y, Izsvak Z, Schmitz D, Hamra FK, Hallermann S, Curtis Garner C, Ackermann F. Loss of Piccolo function in rats induces cerebellar network dysfunction and Pontocerebellar Hypoplasia type 3-like phenotypesJ Neurosci 2020. http://dx.doi.org/10.1523/JNEUROSCI.2316-19.2020.

Faustino Martins JM, Fischer C, Urzi A, Vidal R, Kunz S, Ruffault PL, Kabuss L, Hube I, Gazzerro E, Birchmeier C, Spuler S, Sauer S, Gouti M. Self-Organizing 3D Human Trunk Neuromuscular OrganoidsCell Stem Cell 2020. http://dx.doi.org/10.1016/j.stem.2019.12.007.

Foddis M, Winek K, Bentele K, Mueller S, Blumenau S, Reichhart NN, Crespo-Garcia S, Harnett D, Ivanov A, Meisel A, Joussen A, Strauss O, Beule D, Dirnagl U, Sassi C. An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse modelsJ Cereb Blood Flow Metab 2020, 40. http://dx.doi.org/10.1177/0271678X19827251.

Friedrich D, Brunig FN, Nieuwkoop AJ, Netz RR, Hegemann P, Oschkinat H. Collective exchange processes reveal an active site proton cage in bacteriorhodopsinCommun Biol 2020, 3. http://dx.doi.org/10.1038/s42003-019-0733-7.

Gidon A, Zolnik TA, Fidzinski P, Bolduan F, Papoutsi A, Poirazi P, Holtkamp M, Vida I, Larkum ME. Dendritic action potentials and computation in human layer 2/3 cortical neuronsScience 2020, 367. http://dx.doi.org/10.1126/science.aax6239.

Gonschior H, Haucke V, Lehmann M. Super-Resolution Imaging of Tight and Adherens Junctions: Challenges and Open QuestionsInt J Mol Sci 2020, 21. http://dx.doi.org/10.3390/ijms21030744.

Gowrisankaran S, Houy S, Del Castillo JGP, Steubler V, Gelker M, Kroll J, Pinheiro PS, Schwitters D, Halbsgut N, Pechstein A, van Weering JRT, Maritzen T, Haucke V, Raimundo N, Sorensen JB, Milosevic I. Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectinNat Commun 2020, 11. http://dx.doi.org/10.1038/s41467-020-14993-8.

Guggenmos M, Schmack K, Veer IM, Lett T, Sekutowicz M, Sebold M, Garbusow M, Sommer C, Wittchen HU, Zimmermann US, Smolka MN, Walter H, Heinz A, Sterzer P. A multimodal neuroimaging classifier for alcohol dependenceSci Rep 2020, 10. http://dx.doi.org/10.1038/s41598-019-56923-9.

Gusic M, Schottmann G, Feichtinger RG, Du C, Scholz C, Wagner M, Mayr JA, Lee CY, Yepez VA, Lorenz N, Morales-Gonzalez S, Panneman DM, Rotig A, Rodenburg RJT, Wortmann SB, Prokisch H, Schuelke M. Bi-Allelic UQCRFS1 Variants Are Associated with Mitochondrial Complex III Deficiency, Cardiomyopathy, and Alopecia TotalisAm J Hum Genet 2020, 106. http://dx.doi.org/10.1016/j.ajhg.2019.12.005.

Hausler KG, Endres M, Landmesser U. [Left atrial appendage occlusion in patients with nonvalvular atrial fibrillation : Present evidence, ongoing studies, open questions]Med Klin Intensivmed Notfmed 2020, 115. http://dx.doi.org/10.1007/s00063-018-0500-4.

Heim C. Deficiency of Inflammatory Response to Acute Trauma Exposure as a Neuroimmune Mechanism Driving the Development of Chronic PTSD: Another Paradigmatic Shift for the Conceptualization of Stress-Related Disorders? Am J Psychiatry 2020, 177. http://dx.doi.org/10.1176/appi.ajp.2019.19111189.

Heinz A, Daedelow LS, Wackerhagen C, Di Chiara G. Addiction theory matters-Why there is no dependence on caffeine or antidepressant medicationAddict Biol 2020, 25. http://dx.doi.org/10.1111/adb.12735.

Heinz A, Kiefer F, Smolka MN, Endrass T, Beste C, Beck A, Liu S, Genauck A, Romund L, Banaschewski T, Bermpohl F, Deserno L, Dolan RJ, Durstewitz D, Ebner-Priemer U, Flor H, Hansson AC, Heim C, Hermann D, Kiebel S, Kirsch P, Kirschbaum C, Koppe G, Marxen M, Meyer-Lindenberg A, Nagel WE, Noori HR, Pilhatsch M, Priller J, Rietschel M, Romanczuk-Seiferth N, Schlagenhauf F, Sommer WH, Stallkamp J, Strohle A, Stock AK, Winterer G, Winter C, Walter H, Witt S, Vollstadt-Klein S, Rapp MA, Tost H, Spanagel R. Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)-From trajectories to mechanisms and interventionsAddict Biol 2020, 25. http://dx.doi.org/10.1111/adb.12866.

Heinz A, Kluge U. Fortschr Neurol Psychiatr 2020, 88. http://dx.doi.org/10.1055/a-1062-0515.

Herm J, Schirdewan A, Koch L, Wutzler A, Fiebach JB, Endres M, Kopp UA, Haeusler KG. Impact of atrial fibrillation burden on cognitive function after left atrial ablation - Results of the MACPAF studyJ Clin Neurosci 2020. http://dx.doi.org/10.1016/j.jocn.2019.12.030.

Hoffmann S, Harms L, Schuelke M, Ruckert JC, Goebel HH, Stenzel W, Meisel A. Complement deposition at the neuromuscular junction in seronegative myasthenia gravisActa Neuropathol 2020. http://dx.doi.org/10.1007/s00401-020-02147-5.

Hong H, Zhao K, Huang S, Huang S, Yao A, Jiang Y, Sigrist S, Zhao L, Zhang YQ. Structural remodeling of active zones is associated with synaptic homeostasisJ Neurosci 2020. http://dx.doi.org/10.1523/JNEUROSCI.2002-19.2020.

Huang S, Piao C, Beuschel CB, Gotz T, Sigrist SJ. Presynaptic Active Zone Plasticity Encodes Sleep Need in DrosophilaCurr Biol 2020. http://dx.doi.org/10.1016/j.cub.2020.01.019.

Huehnchen P, Muenzfeld H, Boehmerle W, Endres M. Blockade of IL-6 signaling prevents paclitaxel-induced neuropathy in C57Bl/6 miceCell Death Dis 2020, 11. http://dx.doi.org/10.1038/s41419-020-2239-0.

Ivanova D, Imig C, Camacho M, Reinhold A, Guhathakurta D, Montenegro-Venegas C, Cousin MA, Gundelfinger ED, Rosenmund C, Cooper B, Fejtova A. CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic VesiclesCell Rep 2020, 30. http://dx.doi.org/10.1016/j.celrep.2020.01.079.

Japel M, Gerth F, Sakaba T, Bacetic J, Yao L, Koo SJ, Maritzen T, Freund C, Haucke V. Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast NeurotransmissionCell Rep 2020, 30. http://dx.doi.org/10.1016/j.celrep.2019.12.035.

Kaminski J, Gleich T, Fukuda Y, Katthagen T, Gallinat J, Heinz A, Schlagenhauf F. Association of Cortical Glutamate and Working Memory Activation in Patients With Schizophrenia: A Multimodal Proton Magnetic Resonance Spectroscopy and Functional Magnetic Resonance Imaging StudyBiol Psychiatry 2020, 87. http://dx.doi.org/10.1016/j.biopsych.2019.07.011.

Koehler K, Schuelke M, Hell AK, Schittkowski M, Huebner A, Brockmann K. A novel homozygous nonsense mutation of VPS13B associated with previously unreported features of Cohen syndromeAm J Med Genet A 2020, 182. http://dx.doi.org/10.1002/ajmg.a.61435.

Kornau HC, Kreye J, Stumpf A, Fukata Y, Parthier D, Sammons RP, Imbrosci B, Kurpjuweit S, Kowski AB, Fukata M, Pruss H, Schmitz D. Human Cerebrospinal Fluid Monoclonal LGI1 Autoantibodies Increase Neuronal ExcitabilityAnn Neurol 2020, 87. http://dx.doi.org/10.1002/ana.25666.

Krause P, Volzmann S, Ewert S, Kupsch A, Schneider GH, Kuhn AA. Long-term effects of bilateral pallidal deep brain stimulation in dystonia: a follow-up between 8 and 16 yearsJ Neurol 2020. http://dx.doi.org/10.1007/s00415-020-09745-z.

Kuhn S, Lisofsky N, Banaschewski T, Barker G, Bokde ALW, Bromberg U, Buchel C, Bruhl R, Quinlan EB, Desrivieres S, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Nees F, Orfanos DP, Paus T, Poustka L, Frohner JH, Smolka MN, Walter H, Whelan R, Schumann G, Gallinat J; IMAGEN Consortium. Hierarchical associations of alcohol use disorder symptoms in late adolescence with markers during early adolescenceAddict Behav 2020, 100. http://dx.doi.org/10.1016/j.addbeh.2019.106130.

Kuhn S, Mascherek A, Banaschewski T, Bokde ALW, Buchel C, Quinlan EB, Desrivieres S, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Nees F, Orfanos DP, Paus T, Poustka L, Millenet S, Frohner JH, Smolka MN, Walter H, Whelan R, Schumann G, Lindenberger U, Gallinat J. Predicting change trajectories of neuroticism from baseline brain structure using whole brain analyses and latent growth curve models in adolescentsSci Rep 2020, 10. http://dx.doi.org/10.1038/s41598-020-58128-x.

Makarova KS, Wolf YI, Iranzo J, Shmakov SA, Alkhnbashi OS, Brouns SJJ, Charpentier E, Cheng D, Haft DH, Horvath P, Moineau S, Mojica FJM, Scott D, Shah SA, Siksnys V, Terns MP, Venclovas C, White MF, Yakunin AF, Yan W, Zhang F, Garrett RA, Backofen R, van der Oost J, Barrangou R, Koonin EV. Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variantsNat Rev Microbiol 2020, 18. http://dx.doi.org/10.1038/s41579-019-0299-x.

Malik AR, Lips J, Gorniak-Walas M, Broekaart DWM, Asaro A, Kuffner MTC, Hoffmann CJ, Kikhia M, Dopatka M, Boehm-Sturm P, Mueller S, Dirnagl U, Aronica E, Harms C, Willnow TE. SorCS2 facilitates release of endostatin from astrocytes and controls post-stroke angiogenesisGlia 2020. http://dx.doi.org/10.1002/glia.23778.

Mei J, Kohler J, Winter Y, Spies C, Endres M, Banneke S, Emmrich JV. Automated radial 8-arm maze: A voluntary and stress-free behavior test to assess spatial learning and memory in miceBehav Brain Res 2020, 381. http://dx.doi.org/10.1016/j.bbr.2019.112352.

Minnerup J, Dirnagl U, Schabitz WR. Checklists for Authors Improve the Reporting of Basic Science ResearchStroke 2020, 51. http://dx.doi.org/10.1161/STROKEAHA.119.027626.

Mooney R, Brecht M. Editorial overview: Neurobiology of behaviorCurr Opin Neurobiol 2020. http://dx.doi.org/10.1016/j.conb.2020.01.001.

Neumann B, Angstwurm K, Mergenthaler P, Kohler S, Schonenberger S, Bosel J, Neumann U, Vidal A, Huttner HB, Gerner ST, Thieme A, Steinbrecher A, Dunkel J, Roth C, Schneider H, Schimmel E, Fuhrer H, Fahrendorf C, Alberty A, Zinke J, Meisel A, Dohmen C, Stetefeld HR, German Myasthenic Crisis Study G. Myasthenic crisis demanding mechanical ventilation: A multicenter analysis of 250 casesNeurology 2020, 94. http://dx.doi.org/10.1212/WNL.0000000000008688.

Pechstein A, Tomilin N, Fredrich K, Vorontsova O, Sopova E, Evergren E, Haucke V, Brodin L, Shupliakov O. Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase SeparationCell Rep 2020, 30. http://dx.doi.org/10.1016/j.celrep.2020.01.092.

Plested A, Jayaraman V. Biophysics of Membrane Protein SignalingBiophys J 2020, 118. http://dx.doi.org/10.1016/j.bpj.2020.02.001.

Poirel O, Mamer LE, Herman MA, Arnulf-Kempcke M, Kervern M, Potier B, Miot S, Wang J, Favre-Besse FC, Brabet I, Laras Y, Bertrand HO, Acher F, Pin JP, Puel JL, Giros B, Epelbaum J, Rosenmund C, Dutar P, Daumas S, El Mestikawy S, Pietrancosta N. LSP5-2157 a new inhibitor of vesicular glutamate transportersNeuropharmacology 2020, 164. http://dx.doi.org/10.1016/j.neuropharm.2019.107902.

Praktiknjo SD, Obermayer B, Zhu Q, Fang L, Liu H, Quinn H, Stoeckius M, Kocks C, Birchmeier W, Rajewsky N. Tracing tumorigenesis in a solid tumor model at single-cell resolutionNat Commun 2020, 11. http://dx.doi.org/10.1038/s41467-020-14777-0.

Prehn K, Profitlich T, Rangus I, Hessler S, Witte AV, Grittner U, Ordemann J, Floel A. Bariatric Surgery and Brain Health-A Longitudinal Observational Study Investigating the Effect of Surgery on Cognitive Function and Gray Matter VolumeNutrients 2020, 12. http://dx.doi.org/10.3390/nu12010127.

Purkart L, Sigl-Glockner J, Brecht M. Constant innervation despite pubertal growth of the mouse penisJ Comp Neurol 2020. http://dx.doi.org/10.1002/cne.24892.

Quinlan EB, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Buchel C, Desrivieres S, Flor H, Frouin V, Garavan H, Heinz A, Bruhl R, Martinot JL, Paillere Martinot ML, Nees F, Orfanos DP, Paus T, Poustka L, Hohmann S, Smolka MN, Frohner JH, Walter H, Whelan R, Schumann G; IMAGEN Consortium. Identifying biological markers for improved precision medicine in psychiatryMol Psychiatry 2020, 25. http://dx.doi.org/10.1038/s41380-019-0555-5.

Righetti F, Materne SL, Boss J, Eichner H, Charpentier E, Loh E. Characterization of a transcriptional TPP riboswitch in the human pathogen Neisseria meningitidisRNA Biol 2020. http://dx.doi.org/10.1080/15476286.2020.1727188.

Ringelstein M, Harmel J, Zimmermann H, Brandt AU, Paul F, Haarmann A, Buttmann M, Hummert MW, Trebst C, Schroeder C, Ayzenberg I, Kleiter I, Hellwig K, Havla J, Kumpfel T, Jarius S, Wildemann B, Rommer P, Weber MS, Pellkofer H, Ropke L, Geis C, Retzlaff N, Zettl U, Deppe M, Klotz L, Young K, Stellmann JP, Kaste M, Kermer P, Marouf W, Lauda F, Tumani H, Graf J, Klistorner A, Hartung HP, Aktas O, Albrecht P, Neuromyelitis Optica Study G. Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disordersNeurology 2020, 94. http://dx.doi.org/10.1212/WNL.0000000000008684.

Roayaee M, Rahman RA, Danziger M, Tudge L, Daedelow LS, Heinz A, Wustenberg T. [The others and I: How social interactions change the perception of other persons. The Cyberball paradigm and its indications in the migration context]Fortschr Neurol Psychiatr 2020, 88. http://dx.doi.org/10.1055/a-1033-7304.

Sanguinetti-Scheck JI, Brecht M. Home, head direction stability and grid cell distortionJ Neurophysiol 2020. http://dx.doi.org/10.1152/jn.00518.2019.

Schad DJ, Rapp MA, Garbusow M, Nebe S, Sebold M, Obst E, Sommer C, Deserno L, Rabovsky M, Friedel E, Romanczuk-Seiferth N, Wittchen HU, Zimmermann US, Walter H, Sterzer P, Smolka MN, Schlagenhauf F, Heinz A, Dayan P, Huys QJM. Dissociating neural learning signals in human sign- and goal-trackersNat Hum Behav 2020, 4. http://dx.doi.org/10.1038/s41562-019-0765-5.

Schaefer M, Sarkar S, Theophil I, Leopold K, Heinz A, Gallinat J. Acute and Long-term Memantine Add-on Treatment to Risperidone Improves Cognitive Dysfunction in Patients with Acute and Chronic SchizophreniaPharmacopsychiatry 2020, 53. http://dx.doi.org/10.1055/a-0970-9310.

Schlemm L, Endres M, Nolte CH. Bypassing the Closest Stroke Center for Thrombectomy Candidates: What Additional Delay to Thrombolysis Is Acceptable? Stroke 2020. http://dx.doi.org/10.1161/STROKEAHA.119.027512.

Schlemm L, Endres M, Werring DJ, Nolte CH. Benefit of Intravenous Thrombolysis in Acute Ischemic Stroke Patients With High Cerebral Microbleed BurdenStroke 2020, 51. http://dx.doi.org/10.1161/STROKEAHA.119.027633.

Silva B, Niehage C, Maglione M, Hoflack B, Sigrist SJ, Wassmer T, Pavlowsky A, Preat T. Interactions between amyloid precursor protein-like (APPL) and MAGUK scaffolding proteins contribute to appetitive long-term memory in Drosophila melanogasterJ Neurogenet 2020. http://dx.doi.org/10.1080/01677063.2020.1712597.

Sommer C, Birkenstock J, Garbusow M, Obst E, Schad DJ, Bernhardt N, Huys QM, Wurst FM, Weinmann W, Heinz A, Smolka MN, Zimmermann US. Dysfunctional approach behavior triggered by alcohol-unrelated Pavlovian cues predicts long-term relapse in alcohol dependenceAddict Biol 2020, 25. http://dx.doi.org/10.1111/adb.12703.

Sonderby IE, Gustafsson O, Doan NT, Hibar DP, Martin-Brevet S, Abdellaoui A, Ames D, Amunts K, Andersson M, Armstrong NJ, Bernard M, Blackburn N, Blangero J, Boomsma DI, Bralten J, Brattbak HR, Brodaty H, Brouwer RM, Bulow R, Calhoun V, Caspers S, Cavalleri G, Chen CH, Cichon S, Ciufolini S, Corvin A, Crespo-Facorro B, Curran JE, Dale AM, Dalvie S, Dazzan P, de Geus EJC, de Zubicaray GI, de Zwarte SMC, Delanty N, den Braber A, Desrivieres S, Donohoe G, Draganski B, Ehrlich S, Espeseth T, Fisher SE, Franke B, Frouin V, Fukunaga M, Gareau T, Glahn DC, Grabe H, Groenewold NA, Haavik J, Haberg A, Hashimoto R, Hehir-Kwa JY, Heinz A, Hillegers MHJ, Hoffmann P, Holleran L, Hottenga JJ, Hulshoff HE, Ikeda M, Jahanshad N, Jernigan T, Jockwitz C, Johansson S, Jonsdottir GA, Jonsson EG, Kahn R, Kaufmann T, Kelly S, Kikuchi M, Knowles EEM, Kolskar KK, Kwok JB, Hellard SL, Leu C, Liu J, Lundervold AJ, Lundervold A, Martin NG, Mather K, Mathias SR, McCormack M, McMahon KL, McRae A, Milaneschi Y, Moreau C, Morris D, Mothersill D, Muhleisen TW, Murray R, Nordvik JE, Nyberg L, Olde Loohuis LM, Ophoff R, Paus T, Pausova Z, Penninx B, Peralta JM, Pike B, Prieto C, Pudas S, Quinlan E, Quintana DS, Reinbold CS, Marques TR, Reymond A, Richard G, Rodriguez-Herreros B, Roiz-Santianez R, Rokicki J, Rucker J, Sachdev P, Sanders AM, Sando SB, Schmaal L, Schofield PR, Schork AJ, Schumann G, Shin J, Shumskaya E, Sisodiya S, Steen VM, Stein DJ, Steinberg S, Strike L, Teumer A, Thalamuthu A, Tordesillas-Gutierrez D, Turner J, Ueland T, Uhlmann A, Ulfarsson MO, van 't Ent D, van der Meer D, van Haren NEM, Vaskinn A, Vassos E, Walters GB, Wang Y, Wen W, Whelan CD, Wittfeld K, Wright M, Yamamori H, Zayats T, Agartz I, Westlye LT, Jacquemont S, Djurovic S, Stefansson H, Stefansson K, Thompson P, Andreassen OA, p11.2 European Consortium ftE-CNVwg. Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal gangliaMol Psychiatry 2020, 25. http://dx.doi.org/10.1038/s41380-018-0118-1.

Stanifer ML, Mukenhirn M, Muenchau S, Pervolaraki K, Kanaya T, Albrecht D, Odendall C, Hielscher T, Haucke V, Kagan JC, Bartfeld S, Ohno H, Boulant S. Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cellsNat Microbiol 2020, 5. http://dx.doi.org/10.1038/s41564-019-0594-3.

Stork L, Ellenberger D, Ruprecht K, Reindl M, Beissbarth T, Friede T, Kumpfel T, Gerdes LA, Gloth M, Liman T, Paul F, Bruck W, Metz I. Antibody signatures in patients with histopathologically defined multiple sclerosis patternsActa Neuropathol 2020. http://dx.doi.org/10.1007/s00401-019-02120-x.

Strech D, Weissgerber T, Dirnagl U; QUEST group. Improving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiativePLoS Biol 2020, 18. http://dx.doi.org/10.1371/journal.pbio.3000576.

Stuke F, Brocker AL, Bayer S, Heinz A, Bermpohl F, Lempa G, von Haebler D, Montag C. Between a rock and a hard place: Associations between Mentzos' "dilemma", self-reported interpersonal problems, and psychosocial functioning in individuals with non-affective psychosesClin Psychol Psychother 2020. http://dx.doi.org/10.1002/cpp.2437.

Suenkel C, Cavalli D, Massalini S, Calegari F, Rajewsky N. A Highly Conserved Circular RNA Is Required to Keep Neural Cells in a Progenitor State in the Mammalian BrainCell Rep 2020, 30. http://dx.doi.org/10.1016/j.celrep.2020.01.083.

Suzuki M, Larkum ME. General Anesthesia Decouples Cortical Pyramidal NeuronsCell 2020, 180. http://dx.doi.org/10.1016/j.cell.2020.01.024.

Traub RD, Whittington MA, Maier N, Schmitz D, Nagy JI. Could electrical coupling contribute to the formation of cell assemblies? Rev Neurosci 2020, 31. http://dx.doi.org/10.1515/revneuro-2019-0059.

Wang H, Loerke D, Bruns C, Muller R, Koch PA, Puchkov D, Schultz C, Haucke V. Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathwayJ Biol Chem 2020, 295. http://dx.doi.org/10.1074/jbc.RA119.011774.

Wegner S, Uhlemann R, Boujon V, Ersoy B, Endres M, Kronenberg G, Gertz K. Endothelial Cell-Specific Transcriptome Reveals Signature of Chronic Stress Related to Worse Outcome After Mild Transient Brain Ischemia in MiceMol Neurobiol 2020, 57. http://dx.doi.org/10.1007/s12035-019-01822-3.

Weilnhammer V, Rod L, Eckert AL, Stuke H, Heinz A, Sterzer P. Psychotic Experiences in Schizophrenia and Sensitivity to Sensory EvidenceSchizophr Bull 2020. http://dx.doi.org/10.1093/schbul/sbaa003.

Weinert S, Gimber N, Deuschel D, Stuhlmann T, Puchkov D, Farsi Z, Ludwig CF, Novarino G, Lopez-Cayuqueo KI, Planells-Cases R, Jentsch TJ. Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegenerationEMBO J 2020. http://dx.doi.org/10.15252/embj.2019103358.

Wiegmann C, Mick I, Brandl EJ, Heinz A, Gutwinski S. Alcohol and Dementia - What is the Link? A Systematic ReviewNeuropsychiatr Dis Treat 2020, 16. http://dx.doi.org/10.2147/NDT.S198772.

Woitkuhn J, Ender A, Beuschel CB, Maglione M, Matkovic-Rachid T, Huang S, Lehmann M, Geiger JRP, Sigrist SJ. The Unc13A isoform is important for phasic release and olfactory memory formation at mushroom body synapsesJ Neurogenet 2020. http://dx.doi.org/10.1080/01677063.2019.1710146.

Zolnik TA, Ledderose J, Toumazou M, Trimbuch T, Oram T, Rosenmund C, Eickholt BJ, Sachdev RNS, Larkum ME. Layer 6b Is Driven by Intracortical Long-Range Projection NeuronsCell Rep 2020, 30. http://dx.doi.org/10.1016/j.celrep.2020.02.044.

NCRC Publications

Albert C, Mikolajczak J, Liekfeld A, Piper SK, Scheel M, Zimmermann HG, Nowak C, Dorr J, Bellmann-Strobl J, Chien C, Brandt AU, Paul F, Hoffmann O. Fingolimod after a first unilateral episode of acute optic neuritis (MOVING) - preliminary results from a randomized, rater-blind, active-controlled, phase 2 trialBMC Neurol 2020, 20. http://dx.doi.org/10.1186/s12883-020-01645-z.

Arloth J, Eraslan G, Andlauer TFM, Martins J, Iurato S, Kuhnel B, Waldenberger M, Frank J, Gold R, Hemmer B, Luessi F, Nischwitz S, Paul F, Wiendl H, Gieger C, Heilmann-Heimbach S, Kacprowski T, Laudes M, Meitinger T, Peters A, Rawal R, Strauch K, Lucae S, Muller-Myhsok B, Rietschel M, Theis FJ, Binder EB, Mueller NS. DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learningPLoS Comput Biol 2020, 16. http://dx.doi.org/10.1371/journal.pcbi.1007616.

Asseyer S, Hamblin J, Messina S, Mariano R, Siebert N, Everett R, Kuker W, Bellmann-Strobl J, Ruprecht K, Jarius S, Leite MI, A UB, Paul F, Palace J. Prodromal headache in MOG-antibody positive optic neuritisMult Scler Relat Disord 2020, 40. http://dx.doi.org/10.1016/j.msard.2020.101965.

Backner Y, Ben-Shalom I, Kuchling J, Siebert N, Scheel M, Ruprecht K, Brandt A, Paul F, Levin N. Cortical topological network changes following optic neuritisNeurol Neuroimmunol Neuroinflamm 2020, 7. http://dx.doi.org/10.1212/NXI.0000000000000687.

Bahr LS, Bock M, Liebscher D, Bellmann-Strobl J, Franz L, Pruss A, Schumann D, Piper SK, Kessler CS, Steckhan N, Michalsen A, Paul F, Mahler A. Ketogenic diet and fasting diet as Nutritional Approaches in Multiple Sclerosis (NAMS): protocol of a randomized controlled studyTrials 2020, 21. http://dx.doi.org/10.1186/s13063-019-3928-9.

Burggraaff J, Dorn J, D'Souza M, Morrison C, Kamm CP, Kontschieder P, Tewarie P, Steinheimer S, Sellen A, Dahlke F, Kappos L, Uitdehaag B. Video-Based Pairwise Comparison: Enabling the Development of Automated Rating of Motor Dysfunction in Multiple SclerosisArch Phys Med Rehabil 2020, 101. http://dx.doi.org/10.1016/j.apmr.2019.07.016.

Chien C, Juenger V, Scheel M, Brandt AU, Paul F. Considerations for Mean Upper Cervical Cord Area Implementation in a Longitudinal MRI Setting: Methods, Interrater Reliability, and MRI Quality ControlAJNR Am J Neuroradiol 2020, 41. http://dx.doi.org/10.3174/ajnr.A6394.

Derfuss T, Mehling M, Papadopoulou A, Bar-Or A, Cohen JA, Kappos L. Advances in oral immunomodulating therapies in relapsing multiple sclerosisLancet Neurol 2020. http://dx.doi.org/10.1016/S1474-4422(19)30391-6.

Dorr J, Backer-Koduah P, Wernecke KD, Becker E, Hoffmann F, Faiss J, Brockmeier B, Hoffmann O, Anvari K, Wuerfel J, Piper SK, Bellmann-Strobl J, Brandt AU, Paul F. High-dose vitamin D supplementation in multiple sclerosis - results from the randomized EVIDIMS (efficacy of vitamin D supplementation in multiple sclerosis) trialMult Scler J Exp Transl Clin 2020, 6. http://dx.doi.org/10.1177/2055217320903474.

Druschel C, Ossami Saidy RR, Grittner U, Nowak CP, Meisel A, Schaser KD, Niedeggen A, Liebscher T, Kopp MA, Schwab JM. Clinical decision-making on spinal cord injury-associated pneumonia: a nationwide survey in GermanySpinal Cord 2020. http://dx.doi.org/10.1038/s41393-020-0435-5.

Dusek P, Mekle R, Skowronska M, Acosta-Cabronero J, Huelnhagen T, Robinson SD, Schubert F, Deschauer M, Els A, Ittermann B, Schottmann G, Madai VI, Paul F, Klopstock T, Kmiec T, Niendorf T, Wuerfel J, Schneider SA. Brain iron and metabolic abnormalities in C19orf12 mutation carriers: A 7.0 tesla MRI study in mitochondrial membrane protein-associated neurodegenerationMov Disord 2020, 35. http://dx.doi.org/10.1002/mds.27827.

Faissner S, Graz F, Reinehr S, Petrikowski L, Haupeltshofer S, Ceylan U, Stute G, Winklmeier S, Pache F, Paul F, Ruprecht K, Meinl E, Dick HB, Gold R, Kleiter I, Joachim SC. Binding patterns and functional properties of human antibodies to AQP4 and MOG on murine optic nerve and retinaJ Neuroimmunol 2020, 342. http://dx.doi.org/10.1016/j.jneuroim.2020.577194.

Gkaniatsou T, Papadopoulou A, Paul F, Brandt AU, Oertel FC. Frequency of autoimmune disorders and autoantibodies in European patients with neuromyelitis optica spectrum disordersActa Neurol Belg 2020, 120. http://dx.doi.org/10.1007/s13760-019-01176-6.

Hoffmann S, Harms L, Schuelke M, Ruckert JC, Goebel HH, Stenzel W, Meisel A. Complement deposition at the neuromuscular junction in seronegative myasthenia gravisActa Neuropathol 2020. http://dx.doi.org/10.1007/s00401-020-02147-5.

Hotter B, Hoffmann S, Ulm L, Montaner J, Bustamante A, Meisel C, Meisel A. Inflammatory and stress markers predicting pneumonia, outcome, and etiology in patients with stroke: Biomarkers for predicting pneumonia, functional outcome, and death after strokeNeurol Neuroimmunol Neuroinflamm 2020, 7. http://dx.doi.org/10.1212/NXI.0000000000000692.

Koehler K, Schuelke M, Hell AK, Schittkowski M, Huebner A, Brockmann K. A novel homozygous nonsense mutation of VPS13B associated with previously unreported features of Cohen syndromeAm J Med Genet A 2020, 182. http://dx.doi.org/10.1002/ajmg.a.61435.

Li F, Li Z, Chen Y, Bauer G, Uluk D, Elsner A, Swierzy M, Ismail M, Meisel A, Ruckert JC. Thymectomy in ocular myasthenia gravis before generalization results in a higher remission rateEur J Cardiothorac Surg 2020, 57. http://dx.doi.org/10.1093/ejcts/ezz275.

Magon S, Tsagkas C, Gaetano L, Patel R, Naegelin Y, Amann M, Parmar K, Papadopoulou A, Wuerfel J, Stippich C, Kappos L, Chakravarty MM, Sprenger T. Volume loss in the deep gray matter and thalamic subnuclei: a longitudinal study on disability progression in multiple sclerosisJ Neurol 2020. http://dx.doi.org/10.1007/s00415-020-09740-4.

Neumann B, Angstwurm K, Mergenthaler P, Kohler S, Schonenberger S, Bosel J, Neumann U, Vidal A, Huttner HB, Gerner ST, Thieme A, Steinbrecher A, Dunkel J, Roth C, Schneider H, Schimmel E, Fuhrer H, Fahrendorf C, Alberty A, Zinke J, Meisel A, Dohmen C, Stetefeld HR, German Myasthenic Crisis Study G. Myasthenic crisis demanding mechanical ventilation: A multicenter analysis of 250 casesNeurology 2020, 94. http://dx.doi.org/10.1212/WNL.0000000000008688.

Prehn K, Profitlich T, Rangus I, Hessler S, Witte AV, Grittner U, Ordemann J, Floel A. Bariatric Surgery and Brain Health-A Longitudinal Observational Study Investigating the Effect of Surgery on Cognitive Function and Gray Matter VolumeNutrients 2020, 12. http://dx.doi.org/10.3390/nu12010127.

Ringelstein M, Harmel J, Zimmermann H, Brandt AU, Paul F, Haarmann A, Buttmann M, Hummert MW, Trebst C, Schroeder C, Ayzenberg I, Kleiter I, Hellwig K, Havla J, Kumpfel T, Jarius S, Wildemann B, Rommer P, Weber MS, Pellkofer H, Ropke L, Geis C, Retzlaff N, Zettl U, Deppe M, Klotz L, Young K, Stellmann JP, Kaste M, Kermer P, Marouf W, Lauda F, Tumani H, Graf J, Klistorner A, Hartung HP, Aktas O, Albrecht P, Neuromyelitis Optica Study G. Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disordersNeurology 2020, 94. http://dx.doi.org/10.1212/WNL.0000000000008684.

Scheibe F, Ostendorf L, Reincke SM, Pruss H, von Brunneck AC, Kohnlein M, Alexander T, Meisel C, Meisel A. Daratumumab treatment for therapy-refractory anti-CASPR2 encephalitisJ Neurol 2020, 267. http://dx.doi.org/10.1007/s00415-019-09585-6.

Stork L, Ellenberger D, Ruprecht K, Reindl M, Beissbarth T, Friede T, Kumpfel T, Gerdes LA, Gloth M, Liman T, Paul F, Bruck W, Metz I. Antibody signatures in patients with histopathologically defined multiple sclerosis patternsActa Neuropathol 2020, 139. http://dx.doi.org/10.1007/s00401-019-02120-x.

Tsagkas C, Chakravarty MM, Gaetano L, Naegelin Y, Amann M, Parmar K, Papadopoulou A, Wuerfel J, Kappos L, Sprenger T, Magon S. Longitudinal patterns of cortical thinning in multiple sclerosisHum Brain Mapp 2020. http://dx.doi.org/10.1002/hbm.24940.

Zuber P, Tsagkas C, Papadopoulou A, Gaetano L, Huerbin M, Geiter E, Altermatt A, Parmar K, Ettlin T, Schuster-Amft C, Suica Z, Alrasheed H, Wuerfel J, Kesselring J, Kappos L, Sprenger T, Magon S. Efficacy of inpatient personalized multidisciplinary rehabilitation in multiple sclerosis: behavioural and functional imaging resultsJ Neurol 2020. http://dx.doi.org/10.1007/s00415-020-09768-6.