The NeuroCure Clinical Research Center (NCRC) is a facility of the Cluster that was established in 2008 and will soon be expanded via the NCRC BrainLab module. So far, research in the NCRC has mainly focused on the stable and chronic phases of neurological and psychiatric disorders. But to truly understand the mechanisms of these diseases, and to be able to develop effective therapies, it is also important to work with patients in the hyperacute and unstable phases of such disorders. This would mean having access to preclinical and emergency departments as well as to research programs in neurointensive care and the operating room. The NCRC BrainLab begins at this crucial point, providing the means towards research in each of these areas and connecting researchers with state-of-the-art infrastructure, such as:
- intraoperative imaging (hybrid operating rooms)
- a data warehouse for neurointensive monitoring
- an interdisciplinary emergency unit with on-site magnetic resonance imaging (MRI) and computed tomography imaging (CT) of the brain
- a neuropathological tissue bank
- stereotactic deep brain stimulation (DBS)
- and in vivo electrophysiological recordings
Now clinical researchers will gain access to human clinical data and samples that were previously inaccessible to basic research, thus enabling NeuroCure to deliver a completely new level of translational clinical research. The following projects will be carried out as part of the NCRC (Link).
Due to high development costs and a lack of intellectual property protection, many inventions in the life sciences never find their way into clinical practice. To overcome such hurdles - especially when it comes to neurological and psychiatric disorders - NeuroCure works closely with the very successful program known as SPARK-Berlin.
NeuroCure members Craig Garner and Ulrich Dirnagl first launched SPARK-Berlin in 2014 as a means of promoting the transfer of scientific research into the development of actual diagnostic procedures and new active substances.The program, originally developed at Stanford University in the US, helps scientists put the results of their research projects into action.
Within NeuroCure, a SPARK working group will be established to advise and support NeuroCure scientists on projects with the potential to create clinically relevant neuroscientific therapies, diagnoses, and devices.
Value and Open Science (VOS) Module
Results from basic research often look promising for new therapies, but patients see little benefit. There are numerous causes for this – recent research shows, for example, that the lack of transfer is often a matter of weakness in the planning, execution, and analysis of studies, as well as in (non)reporting of results. Other contributing factors are the frequent misinterpretation of results and a lack of reliability and reproducibility in both preclinical and clinical biomedical research.
The goal of the VOS Module is to support the scientists of NeuroCure in managing their research data and to promote the concept of open science. In this way, NeuroCure looks towards increasing the quality and benefits of future biomedical research.
The establishment of the VOS module takes place in close cooperation with the QUEST Center for Transforming Biomedical Research.
Contact: René Bernard